Structure of PDB 6l5n Chain B

Receptor sequence

>6l5nB (length=377) Species: 9606 (Homo sapiens)

SFSNFPISEETIKLLKGRGVTFLFPIQAKTFHHVYSGKDLIAQARTGTGK
TFSFAIPLIEKLHGELQDRKRGRAPQVLVLAPTRELANQVSKDFSDITKK
LSVACFYGGTPYGGQFERMRNGIDILVGTPGRIKDHIQNGKLDLTKLKHV
VLDEVDQMLDMGFADQVEEILSVAYKKDSEDNPQTLLFSATCPHWVFNVA
KKYMKSTYEQVDLIGKKTQKTAITVEHLAIKCHWTQRAAVIGDVIRVYSG
HQGRTIIFCETKKEAQELSQNSAIKQDAQSLHGDIPQKQREITLKGFRNG
SFGVLVATNVAARGLDIPEVDLVIQSSPPKDVESYIHRSGRTGRAGRTGV
CICFYQHKEEYQLVQVEQKAGIKFKRI

3D structure

• PDB: 6l5n Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
• Chain: B
• Resolution: 2.242 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	P268 T269 R270 G294 G295 Y298 T315 G317 R318 D321 F349 Q352 E446 T447 K448 H468 G469 R476 T494 N495 V496	P82 T83 R84 G108 G109 Y112 T129 G131 R132 D135 F163 Q166 E260 T261 K262 H282 G283 R290 T308 N309 V310
BS02	ANP	B	V206 F208 F210 Q213 T232 G233 G235 K236 T237 F238 D502 R527 R530	V20 F22 F24 Q27 T46 G47 G49 K50 T51 F52 D316 R341 R344
BS03	ANP	B	D346 W381 K555	D160 W195 K369

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding

External links

• PDB: RCSB:6l5n, PDBe:6l5n, PDBj:6l5n
• PDBsum: 6l5n
• PubMed: 32714761
• UniProt: Q9NR30|DDX21_HUMAN Nucleolar RNA helicase 2 (Gene Name=DDX21)