Structure of PDB 6kyp Chain B

Receptor sequence
>6kypB (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
MTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLC
MAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFA
NLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLR
KPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIE
KMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIK
KTESDAALHPLLQEIYRDMY
3D structure
PDB6kyp PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainB
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GW9 B C276 T279 V332 C78 T81 V134
BS02 GW9 B A250 E251 L254 C275 A333 Y334 A52 E53 L56 C77 A135 Y136
BS03 GW9 B K257 L258 N261 I263 H274 C278 H457 K59 L60 N63 I65 H76 C80 H259
BS04 E0O B F273 Q277 S280 Y314 L321 H440 Y464 F75 Q79 S82 Y116 L123 H242 Y266 BindingDB: EC50=55000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:6kyp, PDBe:6kyp, PDBj:6kyp
PDBsum6kyp
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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