Structure of PDB 6kya Chain B

Receptor sequence
>6kyaB (length=730) Species: 9606 (Homo sapiens) [Search protein sequence]
SYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNES
FQGLQNLTKINLNHNPNVNGLNITDGAFLNLKNLRELLLEDNQLPQIPSG
LPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIE
DGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFK
GLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLN
LSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILD
LSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQL
PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVFDPHSNFYH
FTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ
VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFR
IAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNR
LDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTEL
HINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLL
SHNRISHLSLKHLDLSSNLLKTINKLSMLELHGNPFECTCDIGDFRRWMD
EHLNVKIPRLVDVICASPGDQRGKSIVSLE
3D structure
PDB6kya Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
ChainB
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DY3 B F494 F495 A518 F425 F426 A449 BindingDB: IC50=30nM,Kd=225nM
BS02 DY3 B Y348 K350 G351 V378 Y305 K307 G308 V335 BindingDB: IC50=30nM,Kd=225nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kya, PDBe:6kya, PDBj:6kya
PDBsum6kya
PubMed32233366
UniProtQ9NR97|TLR8_HUMAN Toll-like receptor 8 (Gene Name=TLR8)

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