Structure of PDB 6kuv Chain B

Receptor sequence
>6kuvB (length=705) Species: 1173138 (Influenza D virus (D/swine/Oklahoma/1334/2011)) [Search protein sequence]
MEINPYLLMLNNDITSMISLTYPYTGAPPMSHGTSTKYSMETVSRTYSYS
RTKKEVPSGIFPIERRKFCNTIEDKENLEKPNGNVDINFMLSLAEMLEEK
MGKGFFKFCANEAEAEILKMHFSKLTEGRQTYDWTSERNMPAATALQLTV
DAIQETQGTFKGTTMVEYCNKILEMMDWPEVKFKKVTLMITKIGREEFIK
RICTINTMAKDGERGKYKRRAIATPGMGIRPFSKIVETLAQKICERLAES
GLPVEKKAKLKTTVSSTNSKLQEGQFMVNITGDNSKWNECQQPEAYLAML
AYITKDSSNLMKDLCSVAPTLFCNKYVKMGQGFRAKNKRKTKEIVIPAKK
MKERKELMNAEWRDLFETIEPYMDGECCFLGGGMLMGMFNMLSTVFGVMT
LNYREERNCYWTGLQSSDDFVLFCISRTWPEMEMTILKFIAVCKLMGINM
SLEKSYGCLPELFEFTSMFFSGDFVSNIALELPAFTTAGMNEGTDFTAAM
SVIRTNMINNGLSPGTALMALRICLQEFRATYRVHPYDSGVKNHRMKIIR
KFIETIENKDGLLISDGGKLMNNISSLHIPEEILKEDLMDPSYRNRVFNP
RNPFTQFAVVSTHSFRTRSNRTLLNTDMRAMALEEKRYQVVCNMYRSVFE
SADVNTPIGSMSMGEAIEAKILDRARTQFENGIIGGEEYSEIKRLIEDAK
RQRLS
3D structure
PDB6kuv Structural insight into RNA synthesis by influenza D polymerase.
ChainB
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 rna B A558 R561 H563 H572 A530 R533 H535 H544
BS02 rna B H32 T34 K37 K239 R358 W386 H32 T34 K37 K218 R334 W362
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication

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Molecular Function

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Biological Process
External links
PDB RCSB:6kuv, PDBe:6kuv, PDBj:6kuv
PDBsum6kuv
PubMed31209309
UniProtK9LH03

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