Structure of PDB 6ktq Chain B

Receptor sequence
>6ktqB (length=398) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence]
KHHHHHHHHGGLVPRGSLHMKVGILDSTLREGEQTPGVVFTTDQRVEIAK
ALSDIGVQMIEAGHPAVSPDIYEGIRRIIKLKREGVIKSEIVAHSRAVKR
DIEVGAEIEADRIAIFYGISDTHLKAKHHTTRDEALRSIAETVSYAKSHG
VKVRFTAEDATRADYQYLLEVIKTVRDAGADRVSIADTVGVLYPSRTREL
FKDLTSRFPDIEFDIHAHNDLGMAVANVLAAAEGGATIIHTTLNGLGERV
GIAPLQVVAAALKYHFGIEVVDLKKLSEVASLVEKYSGIALPPNFPITGD
YAFVHKAGVHVAGVLNDPKTYEFLPPETFGRSRDYVIDKYTGKHAVKDRF
DRLGVKLTDSEIDQVLAKIKSNPNVRFYRDVDLLELAESVTGRLEHHH
3D structure
PDB6ktq Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius.
ChainB
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.14: homocitrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E20 H205 H207 E31 H216 H218
BS02 AKG B R19 T145 S173 T177 H205 H207 R30 T156 S184 T188 H216 H218
BS03 COA B V56 R85 A86 F105 Y106 H117 E147 V67 R96 A97 F116 Y117 H128 E158
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004410 homocitrate synthase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid

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Molecular Function
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Biological Process
External links
PDB RCSB:6ktq, PDBe:6ktq, PDBj:6ktq
PDBsum6ktq
PubMed32897601
UniProtQ4J989|HOSA_SULAC Homocitrate synthase (Gene Name=Saci_1304)

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