Structure of PDB 6kr3 Chain B

Receptor sequence
>6kr3B (length=836) Species: 11060 (dengue virus type 2) [Search protein sequence]
TLGEKWKNRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSR
GSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVKEVKGLTKGG
PGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVE
AGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVR
NPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVD
LGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHG
SYETKQTSSMVNGVVRLLTKPWDIIPMVTQMAMPFGQQRVFKEKVDTRTQ
EPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNWKSAREAV
EDSGFWELVDKERNLHLEGKCETCVYNMMRAIWYMWLGARFLEFEALGFL
NEDHWFSRENSLSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRI
TLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDI
ISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIA
VKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASALTALNDMGKVRKDIQ
QWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQ
GAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSR
TTHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLGKREDQWCG
SLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMP
3D structure
PDB6kr3 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase.
ChainB
Resolution2.931 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B R68 L70 R61 L63
BS02 SAH B G81 C82 G86 W87 T104 K105 H110 D131 V132 F133 D146 I147 G74 C75 G79 W80 T97 K98 H103 D124 V125 F126 D139 I140
BS03 ZN B E438 H442 C447 C450 E412 H416 C421 C424
BS04 ZN B H712 H714 C728 C847 H670 H672 C686 C799
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6kr3, PDBe:6kr3, PDBj:6kr3
PDBsum6kr3
PubMed32357182
UniProtQ91H74

[Back to BioLiP]