Structure of PDB 6kr2 Chain B

Receptor sequence
>6kr2B (length=843) Species: 11060 (dengue virus type 2) [Search protein sequence]
TLGEKWKNRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSR
GSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCGGLKNVKEVKGLTKGG
PGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVE
AGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVR
NPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVD
LGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHG
SYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKE
KVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNS
AREAVEDSGFWELVDKERNLHLEGKCETCVYNMREKKLGEFGKAIWYMWL
GARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYILRDVSKKEGGA
MYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVR
VQRPTPRGTVMDIISRRDQRGVTYGLNTFTNMEAQLIRQMEGEGVFKSIQ
HLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVVKPLDDRFASALTALND
MGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDE
LIGRARISQSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHW
VPTSRTTHATHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLG
KREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYM
3D structure
PDB6kr2 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase.
ChainB
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B E438 H442 C447 C450 E417 H421 C426 C429
BS02 ZN B H712 H714 C728 C847 H679 H681 C695 C807
BS03 SAH B S56 G81 C82 G83 G86 W87 K105 H110 V130 V132 F133 D146 S49 G74 C75 G76 G79 W80 K98 H103 V123 V125 F126 D139
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6kr2, PDBe:6kr2, PDBj:6kr2
PDBsum6kr2
PubMed32357182
UniProtQ91H74

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