Structure of PDB 6kpt Chain B

Receptor sequence
>6kptB (length=608) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
MSHYKSNVRDQVFNLFEVFGVDKVLGADKFSDLDADTAREMLTEIARLAE
GPIAESFVEGDRNPPVFDPETHTVTLPEGFKKSMRALFDGGWDKVGLAEH
LGGIPMPRALQWALIEHILGANPAAYMYAMGPGMSEIFYNNGTDEQKKWA
TIAAERGWGATMVLTEPDAGSDVGAGRTKAVQQPDGTWHIEGVKRFITSA
DSDDLFENIMHLVLARPEGAGPGTKGLSLFFVPKFHFDHETGEIGERNGV
FVTNVEHKMGLKVSATCELSLGQHGIPAVGWLVGEVHNGIAQMFDVIEQA
RMMVGTKAIATLSTGYLNALEYAKERVQGADMTQMTDKTAPRVTITHHPD
VRRSLMTQKAYAEGLRAIYLYTATFQDAEVAQAVHGVDGDLAARVNDLLL
PIVKGFGSETAYAKLTESLQTLGGSGFLQDYPIEQYIRDSKIDSLYEGTT
AIQAQDFFFRKIIRDKGQALAYVAGEIEQFIKNNGRLKTERELLATALAD
VQGMAASLTGYLMAAQEDAASIYKVGLGSVRFLMAVGDLLSGWLLARQAA
VAIEKLDAGATGADKSFYEGKIAAASFFAKNMLPLLTSTRQIIENLDNDV
MELDEAAF
3D structure
PDB6kpt Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria.
ChainB
Resolution1.963 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
1.3.8.7: medium-chain acyl-CoA dehydrogenase.
1.3.8.8: long-chain-acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B R326 I345 H348 Q420 T421 G423 G424 R326 I345 H348 Q420 T421 G423 G424
BS02 FAD B M162 L164 T165 G170 S171 F196 I197 T198 I442 Y446 T449 Q455 M162 L164 T165 G170 S171 F196 I197 T198 I442 Y446 T449 Q455
Gene Ontology
Molecular Function
GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0070991 medium-chain fatty acyl-CoA dehydrogenase activity
Biological Process
GO:0006631 fatty acid metabolic process
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kpt, PDBe:6kpt, PDBj:6kpt
PDBsum6kpt
PubMed32601219
UniProtQ3L887|FADE5_MYCS2 Broad-specificity linear acyl-CoA dehydrogenase FadE5 (Gene Name=fadE5)

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