Structure of PDB 6kln Chain B

Receptor sequence
>6klnB (length=372) Species: 10090 (Mus musculus) [Search protein sequence]
ETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSY
VGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPT
LLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVL
DSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTT
AEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNE
RFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGT
TMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQ
QMWITKQEYDEAGPSIVHRKCF
3D structure
PDB6kln Cryo-EM structures of cardiac thin filaments reveal the 3D architecture of troponin.
ChainB
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G13 S14 D157 K213 E214 G302 Y306 K336 G10 S11 D154 K210 E211 G299 Y303 K333
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0009612 response to mechanical stimulus
GO:0010628 positive regulation of gene expression
GO:0030240 skeletal muscle thin filament assembly
GO:0035865 cellular response to potassium ion
GO:0043503 skeletal muscle fiber adaptation
GO:0048545 response to steroid hormone
GO:0048741 skeletal muscle fiber development
GO:0090131 mesenchyme migration
Cellular Component
GO:0001725 stress fiber
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
GO:0005884 actin filament
GO:0015629 actin cytoskeleton
GO:0030017 sarcomere
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0032991 protein-containing complex
GO:0044297 cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kln, PDBe:6kln, PDBj:6kln
PDBsum6kln
PubMed31954841
UniProtP68134|ACTS_MOUSE Actin, alpha skeletal muscle (Gene Name=Acta1)

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