Structure of PDB 6kku Chain B

Receptor sequence
>6kkuB (length=537) Species: 9606 (Homo sapiens) [Search protein sequence]
PSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTL
LTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAM
YILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIFLTFMTLV
VFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTL
SRDQFDICAKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEI
PGIPGAAAGVLQENLWSAYLEKGDIVEKHGLPSADAPSLKESLPLYVVAD
IATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIITTSLV
YFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFST
CGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIA
ELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYH
WALSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYI
3D structure
PDB6kku Cryo-EM structures of the human cation-chloride cotransporter KCC1.
ChainB
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B K387 M576 K272 M461
BS02 DU0 B Y636 V640 M647 Y521 V525 M532
BS03 CL B G433 I434 M435 Y589 G318 I319 M320 Y474
BS04 DU0 B L203 I564 Y637 L88 I449 Y522
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015293 symporter activity
GO:0015377 chloride:monoatomic cation symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0006884 cell volume homeostasis
GO:0007268 chemical synaptic transmission
GO:0055064 chloride ion homeostasis
GO:0055075 potassium ion homeostasis
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045202 synapse

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Molecular Function
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Cellular Component
External links
PDB RCSB:6kku, PDBe:6kku, PDBj:6kku
PDBsum6kku
PubMed31649201
UniProtQ9UP95|S12A4_HUMAN Solute carrier family 12 member 4 (Gene Name=SLC12A4)

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