Structure of PDB 6kk4 Chain B

Receptor sequence
>6kk4B (length=161) Species: 64320 (Zika virus) [Search protein sequence]
ETTDGVYRVMTRRLLGSTQVGVGVMQEGVFHTMWHVTKGAALRSGEGRLD
PYWGDVKQDLVSYCGPWKLDAAWDGLSEVQLLAVPPGERAKNIQTLPGIF
KTKDGDIGAVALDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAIT
QGKREEETPVE
3D structure
PDB6kk4 Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika, West Nile and Dengue viruses.
ChainB
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DE0 B H51 D129 Y130 A132 S135 G151 N152 G153 V155 Y161 H35 D113 Y114 A116 S119 G135 N136 G137 V139 Y145
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6kk4, PDBe:6kk4, PDBj:6kk4
PDBsum6kk4
PubMed32501637
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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