Structure of PDB 6kcl Chain B

Receptor sequence
>6kclB (length=545) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEV
NVENYLLECNNIIVKNDEIMKNNLSYFYNLTVVVKTFVNDPLSMLVVIKY
IEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLQEIINNMV
DNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRM
KEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNFVEPKRAVQRMF
EMINEGASVIDIGGEKISERDLVVPVLQLFQKEWNDAKPIISIDTINYNV
FKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTM
DELTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSI
KLLQNIHVYDEYPLFIGYSRKRFIAHCMNDKDQLLYQKNICGGLAIASYS
YYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE
3D structure
PDB6kcl The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainB
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PE0 B D482 N502 M529 D575 F580 G605 K609 R686 D344 N364 M391 D437 F442 G467 K471 R509
BS02 ATP B L181 K185 D208 D210 I211 N312 I313 E314 F315 L316 S317 L145 K149 D159 D161 I162 N202 I203 E204 F205 L206 S207
BS03 MG B D208 D210 D159 D161
BS04 CA B E42 G46 K47 E99 E38 G42 K43 E72
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6kcl, PDBe:6kcl, PDBj:6kcl
PDBsum6kcl
PubMed31883412
UniProtQ25704

[Back to BioLiP]