Structure of PDB 6kc5 Chain B

Receptor sequence
>6kc5B (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
GIDCPKCKFSYGCMHFHCTQCRHQFCSGCYNAFYAKNKCPEPNCRVKKSL
HGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAGGCRVIEQKACGK
ETPAGYAGLCQAHYKEYLVSLINAHSLDPATLYEVEELETATERYLHVRP
QPLAGEDPPAYQARLLQKLTEEVPLGQSIPRR
3D structure
PDB6kc5 Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
ChainB
Resolution1.543 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C871 C874 C890 C4 C7 C18
BS02 ZN B C898 C901 H926 C930 C26 C29 H54 C58
BS03 ZN B C911 C916 H923 H925 C39 C44 H51 H53
BS04 ZN B C969 C986 C998 H1001 C90 C98 C110 H113
BS05 D5U B G884 C885 M886 H887 F905 R935 G12 C13 M14 H15 F33 R63
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Cellular Component
GO:0071797 LUBAC complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:6kc5, PDBe:6kc5, PDBj:6kc5
PDBsum6kc5
PubMed32246052
UniProtQ96EP0|RNF31_HUMAN E3 ubiquitin-protein ligase RNF31 (Gene Name=RNF31)

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