Structure of PDB 6k9h Chain B

Receptor sequence
>6k9hB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
QLTAAQELMIQQLVAAQLQVTPWPASQQRFAHFTELAIISVQEIVDFAKQ
VPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECILKDFTYSKDDF
HRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPG
RVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVF
ALRLQKLPPLLSEIWDVHKILHRLLQD
3D structure
PDB6k9h Discovery of new LXR beta agonists as glioblastoma inhibitors.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D40 B F271 I309 M312 T316 F340 I353 H435 F33 I71 M74 T78 F100 I113 H195 MOAD: Ki=600nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6k9h, PDBe:6k9h, PDBj:6k9h
PDBsum6k9h
PubMed32248003
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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