Structure of PDB 6k7s Chain B

Receptor sequence
>6k7sB (length=286) Species: 6689 (Penaeus vannamei) [Search protein sequence]
MRHDEYQYLDLIRQIMRTGNRKGTGTGTISMFGAQMRYSLRDGIFPLLTT
KRVFWRGVAEELLWFVRGSTNAKELQEKDIHIWDGNSSKEFLNKMGFHDR
EEGDLGPVYGFQWRHFGAPYADMHTDYTGQGVDQLQQVIDTIKNNPDDRR
IIMCAWNPVDVPKMALPPCHCLCQFYVANGELSCQLYQRSADMGLGVPFN
IASYALLTYMIAHVTDLKPGDFVHTLGDAHVYSNHCEALEEQLKREPRPF
PSLKIKRKVENISDFKFEDFELDGYKPHPKIKMEMA
3D structure
PDB6k7s Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed.
ChainB
Resolution1.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E63 W85 Y111 C171 R191 D194
Catalytic site (residue number reindexed from 1) E61 W83 Y109 C169 R189 D192
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B R151 R152 R149 R150
BS02 UMP B C171 R191 S192 D194 N202 H232 Y234 C169 R189 S190 D192 N200 H230 Y232
BS03 D16 B F56 I84 W85 D194 L197 G198 F201 M287 F54 I82 W83 D192 L195 G196 F199 M285
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6k7s, PDBe:6k7s, PDBj:6k7s
PDBsum6k7s
PubMed
UniProtA0A423U5Z1

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