Structure of PDB 6k5l Chain B

Receptor sequence
>6k5lB (length=555) Species: 1045010 (Escherichia coli O157) [Search protein sequence]
GLELLIAQTILQGFDAQYGRFLEVTSGAQQRFEQADWHAVQQAMKNRIHL
YDHHVGLVVEQLRCITDAEFLLRVKEHYTRLLPDYPRFEIAESFFNSVYC
RLFDHRSLTPERLFIFSSQPERRFRTIPRPLAKDFHPDHGWESLLMRVIS
DLPLRLHWQNKSRDIHYIIRHLTETLGPENLSKSHLQVANELFYRNKAAW
LVGKLITPSGTLPFLLPIHQTDDGELFIDTCLTTTAEASIVFGFARSYFM
VYAPLPAALVEWLREILPGKTTAELYMAIGCQKHAKTESYREYLVYLQGC
NEQFIEAPGIRGMVMLVFTLPGFDRVFKVIKDKFAPQKEMSAAHVRACYQ
LVKEHDRVGRMADTQEFENFVLEKRHISPALMELLLQEAAEKITDLGEQI
VIRHLYIERRMVPLNIWLEQVEGQQLRDAIEEYGNAIRQLAAANIFPGDM
LFKNFGVTRHGRVVFYDYDEICYMTEVNFRDIPPPWYSVSPGDVFPEEFR
HWLCADPRIGPLFEEMHADLFRADYWRALQNRIREGHVEDVYAYRRRQRF
SVRYG
3D structure
PDB6k5l Characterization of metal binding of bifunctional kinase/phosphatase AceK and implication in activity modulation.
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.5: [isocitrate dehydrogenase (NADP(+))] kinase.
3.1.3.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP B N104 S105 H113 L116 K291 K294 T295 Y298 F375 N377 N96 S97 H105 L108 K283 K286 T287 Y290 F367 N369
BS02 ADP B G317 I318 G320 V322 M323 V325 K336 E416 M419 Y474 D475 G309 I310 G312 V314 M315 V317 K328 E408 M411 Y466 D467
BS03 MN B N462 D475 N454 D467
BS04 MN B D475 D477 D467 D469
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008772 [isocitrate dehydrogenase (NADP+)] kinase activity
GO:0016208 AMP binding
GO:0016788 hydrolase activity, acting on ester bonds
GO:0016791 phosphatase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006006 glucose metabolic process
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k5l, PDBe:6k5l, PDBj:6k5l
PDBsum6k5l
PubMed31235769
UniProtP11071|ACEK_ECOLI Isocitrate dehydrogenase kinase/phosphatase (Gene Name=aceK)

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