Structure of PDB 6k3g Chain B

Receptor sequence

>6k3gB (length=356) Species: 4058 (Catharanthus roseus)

SPEVEHPVKAFGWAARDTSGHLSPFHFSRRATGEHDVQFKVLYCGICHSD
LHMIKNEWGFTKYPIVPGHEIVGIVTEVGSKVEKFKVGDKVGVGCLVGSC
RKCDMCTKDLENYCPGQILTYSATYTDGTTTYGGYSDLMVADEHFVIRWP
ENLPMDIGAPLLCAGITTYSPLRYFGLDKPGTHVGVVGLGGLGHVAVKFA
KAFGAKVTVISTSESKKQEALEKLGADSFLVSRDPEQMKAAAASLDGIID
TVSAIHPIMPLLSILKSHGKLILVGAPEKPLELPSFPLIAGRKIIAGSAI
GGLKETQEMIDFAAKHNVLPDVELVSMDYVNTAMERLLKADVKYRFVIDV
ANTLKS

3D structure

• PDB: 6k3g Structural studies on 10-hydroxygeraniol dehydrogenase: A novel linear substrate-specific dehydrogenase from Catharanthus roseus.
• Chain: B
• Resolution: 2.41 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C50 S52 H55 H72 C166
• Catalytic site (residue number reindexed from 1): C47 S49 H52 H69 C163
• Enzyme Commision number: 1.1.1.324: 8-hydroxygeraniol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	B	H51 S52 H55 W61 C166 T170 G191 L192 G193 G194 L195 S214 T215 S216 K219 T254 V255 S256 A257 V277 G278 A279 A302 I303 R348	H48 S49 H52 W58 C163 T167 G188 L189 G190 G191 L192 S211 T212 S213 K216 T251 V252 S253 A254 V274 G275 A276 A299 I300 R345
BS02	ZN	B	C50 H72 C166	C47 H69 C163
BS03	ZN	B	C103 C106 C109 C117	C100 C103 C106 C114

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0045551 cinnamyl-alcohol dehydrogenase activity
• GO:0046872 metal ion binding
• GO:0102311 8-hydroxygeraniol dehydrogenase activity

Biological Process

• GO:0009809 lignin biosynthetic process

External links

• PDB: RCSB:6k3g, PDBe:6k3g, PDBj:6k3g
• PDBsum: 6k3g
• PubMed: 32181958
• UniProt: Q6V4H0|10HGO_CATRO 8-hydroxygeraniol dehydrogenase (Gene Name=10HGO)