Structure of PDB 6k1r Chain B

Receptor sequence
>6k1rB (length=305) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
SHMTWHILGAGSLGSLWAARLGRAGLPVRLILRDRQRLRRYQQAGGLSLV
EDGQASLYPIAAETPDGGQPIQRLLLACKAYDAEEAASSVAHRLAGNAEL
LLLQNGLGSQQAVAARLPRSRCLFASSTEGAFRDGDFRVVFAGRGHTWLG
DPRDTNAPAWLTQLSQAGIPHSWSDDILERLWRKLALNCAINPLTVLHDC
RNGGLRQHPEEIAALCDELGQLLHASGYDAAARSLLEDVRAVIDATAANY
SSMHQDVTRGRRTEIGYLLGYACQHGQRLGLPLPRLGTLLARLQAHLRQR
GLPDR
3D structure
PDB6k1r Crystallographic and biophysical analyses of Pseudomonas aeruginosa ketopantoate reductase: Implications of ligand induced conformational changes in cofactor recognition.
ChainB
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.169: 2-dehydropantoate 2-reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KPL B N190 N200 S249 S250 N192 N202 S251 S252
BS02 NAD B G7 A8 G9 S10 L11 R31 A75 C76 D80 N103 E127 G128 A129 R131 E262 G9 A10 G11 S12 L13 R33 A77 C78 D82 N105 E129 G130 A131 R133 E264
Gene Ontology
Molecular Function
GO:0008677 2-dehydropantoate 2-reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0015940 pantothenate biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k1r, PDBe:6k1r, PDBj:6k1r
PDBsum6k1r
PubMed34757166
UniProtQ9HW09|PANE_PSEAE 2-dehydropantoate 2-reductase (Gene Name=panE)

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