Structure of PDB 6jwx Chain B

Receptor sequence
>6jwxB (length=526) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
TNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETVPNYINE
LMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNVENYLLECN
NIIVKNDEIYFYNLTVVVKTFVNDPLSMLVVIKYIEELMKRIIDIDILFF
NDFTIFMKNIKLEKNMIYKILSKYIHLIINNMVDNIEFLSIPHVYTTHRY
SILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRIYV
LKDRISYLKEKTNIVGILNVNEPKRAVQRMFEMINEGASVIDIGGEISER
DLVVPVLQLFQKEWNDAKPIISIDTINYNVFKECVDNDLVDILNDISACT
NNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQR
LNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSR
KRFIAHCMNDKDQLLYQKNICGGLAIASYSYYKKVDLIRVHDVLETKSVL
DVLTKIDQVKDPNSSSVDKLAAALEH
3D structure
PDB6jwx The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainB
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CKL B D482 N502 I504 M529 D575 F580 F603 G605 K609 R610 R686 D324 N344 I346 M371 D417 F422 F445 G447 K451 R452 R489
BS02 AMP B K185 D208 D210 I211 N312 I313 F315 L316 S317 H320 K133 D144 D146 I147 N185 I186 F188 L189 S190 H193
BS03 MG B D208 D210 D144 D146
BS04 CA B E42 G46 E99 E28 G32 E62
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jwx, PDBe:6jwx, PDBj:6jwx
PDBsum6jwx
PubMed31883412
UniProtQ25704

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