Structure of PDB 6jww Chain B

Receptor sequence

>6jwwB (length=559) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPEYIYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILK
EVNVENYLLECNNIIVKNDEIMYFYNLTVVVKTFVNDPLSMLVVIKYIEE
LMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEQEIINNMVDN
IEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKE
QYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYFVEPKRAVQRMFE
MINEGASVIDIGGESFGNPKISERDLVVPVLQLFQKEWNDIKNKIVKCDA
KPIISIDTINYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYS
VVLMHKRGNPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFD
IGLGFAKKHDQSIKLLQNIHVYDEYPLFIGYSRKRFITHCMNDDKDQLLY
QKNICGGLAIASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSS
VDKLAAALE

3D structure

PDB

6jww The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	XTZ	B	F436 D482 N502 I504 M529 P535 M538 D539 D575 F580 G605 K609 R610 R686	F316 D357 N377 I379 M404 P410 M413 D414 D450 F455 G480 K484 R485 R523
BS02	AMP	B	L181 D208 D210 I211 N312 F315 L316 S317 H320	L142 D156 D158 I159 N200 F203 L204 S205 H208
BS03	MG	B	D208 D210	D156 D158
BS04	CA	B	E42 G46 E99	E38 G42 E74

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jww, PDBe:6jww, PDBj:6jww
PDBsum	6jww
PubMed	31883412
UniProt	Q25704

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