Structure of PDB 6jwu Chain B

Receptor sequence
>6jwuB (length=534) Species: 5833 (Plasmodium falciparum) [Search protein sequence]
QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVNV
ENYLLECNNIIVKNDFYNLTVVVKTFVNDPLSMLVVIKYIEELMIIDIDI
LFFNDFTIFMKNIKLEKNMIYKILSKYIHLINNMVDNIEFLSIPHVYTTH
RYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINIKENNKRI
YVLKDRISYLKEKTNIVGILNVNYVEPKRAVQRMFEMINEGASVIDIGGE
KISERDLVVPVLQLFQKEWNDIKCDAKPIISIDTINYNVFKECVDNDLVD
ILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVY
DIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDE
YPLFIGYSRKRFIAHCMNDKDQLLYQKNICGGLAIASYSYYKKVDLIRVH
DVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE
3D structure
PDB6jwu The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.
ChainB
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XTZ B D482 N502 M529 M538 D539 D575 F580 G605 K609 R610 R686 D333 N353 M380 M389 D390 D426 F431 G456 K460 R461 R498
BS02 AMP B D208 I211 N312 I313 F315 S317 H320 D147 I150 N187 I188 F190 S192 H195
BS03 MG B D208 D210 D147 D149
BS04 CA B E42 G46 K47 E99 E38 G42 K43 E70
Gene Ontology
Molecular Function
GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156 dihydropteroate synthase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0016310 phosphorylation
GO:0042558 pteridine-containing compound metabolic process
GO:0044237 cellular metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046656 folic acid biosynthetic process
Cellular Component
GO:0005740 mitochondrial envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jwu, PDBe:6jwu, PDBj:6jwu
PDBsum6jwu
PubMed31883412
UniProtQ25704

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