Structure of PDB 6jws Chain B

Receptor sequence

>6jwsB (length=589) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

QELILSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYL
YETVPEYIVNYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSI
LKEVNVENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSMLVVI
KYIEELMKIIDIDILFFNDFTIFMKNIKLEKNMIYKILSKYIHLEPQEII
NNMVDNIEFLSIPHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKY
VSRMKEQYNINIKENNKRIYVLKDRISYLKEKTNIVGILNVNYDSFSDGG
IFVEPKRAVQRMFEMINEGASVIDIGGESSGPFVIPNPKISERDLVVPVL
QLFQKEWNDIKNKIVKCDAKPIISIDTINYNVFKECVDNDLVDILNDISA
CTNNPEIIKLLKKKNKFYSVVLMHKRGNPHTMDKLTNYDNLVYDIKNYLE
QRLNFLVLNGIPRYRILFDIGLGFAKKHDQSIKLLQNIHVYDEYPLFIGY
SRKRFIAHCMNHNWMFQMNYMRKDKDQLLYQKNICGGLAIASYSYYKKVD
LIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE

3D structure

PDB

6jws The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PT1	B	G437 P438 D482 N502 M529 D575 F580 G605 K609 R610 R686	G331 P332 D376 N396 M423 D469 F474 G499 K503 R504 R553
BS02	ATP	B	D208 D210 I211 N312 I313 E314 F315 L316 S317 H320	D161 D163 I164 N206 I207 E208 F209 L210 S211 H214
BS03	MG	B	D208 D210	D161 D163
BS04	CA	B	E42 G46 E99	E38 G42 E76
BS05	MG	B	M648 D689 E692	M515 D556 E559

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6jws, PDBe:6jws, PDBj:6jws
PDBsum	6jws
PubMed	31883412
UniProt	Q25704

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