Structure of PDB 6jwr Chain B

Receptor sequence

>6jwrB (length=549) Species: 5833 (Plasmodium falciparum) [Search protein sequence]

LSEENKTNIAVLNLGTNDRRNAVLILETALHLVEKYLGKIINTSYLYETV
PEYINYINELMQNLEESKYEENKELIDKCEEYETFLKNGKVDNSILKEVN
VENYLLECNNIIVKNDEIMKNSYFYNLTVVVKTFVNDPLSMLVVIKYIEE
LMKIIDIDILFFNDFTIFMKNIYKILSKYIHLDPQEIINNMVDNIEFLSI
PHVYTTHRYSILLCLNDMIPEYKHNVLNNTIRCLYNKYVSRMKEQYNINI
KENNKRIYVLKDRISYLKEKTNIVGILNVNYGIFVEPKRAVQRMFEMINE
GASVIDIGGESSAPFVIPNPKISERDLVVPVLQLFQKEWNDAKPIISIDT
INYNVFKECVDNDLVDILNDISACTNNPEIIKLLKKKNKFYSVVLMHKRG
NPHTMDKLTNYDNLVYDIKNYLEQRLNFLVLNGIPRYRILFDIGLGFAKK
HDQSIKLLQNIHVYDEYPLFIGYSRKRFIAHCMDKDQLLYQKNICGGLAI
ASYSYYKKVDLIRVHDVLETKSVLDVLTKIDQVKDPNSSSVDKLAAALE

3D structure

PDB

6jwr The structure of Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase reveals the basis of sulfa resistance.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.5.1.15: dihydropteroate synthase.
2.7.6.3: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	PT1	B	S436 A437 P438 D482 N502 I504 M529 D575 F580 G605 K609 R610 R686	S312 A313 P314 D349 N369 I371 M396 D442 F447 G472 K476 R477 R513
BS02	AMP	B	L181 K185 D208 I211 F315 L316 S317 H320	L142 K146 D156 I159 F197 L198 S199 H202
BS03	MG	B	D208 D210	D156 D158
BS04	CA	B	E42 G46 K47 E99	E34 G38 K39 E71

Gene Ontology

	Molecular Function
GO:0003848	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
GO:0004156	dihydropteroate synthase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0016310	phosphorylation
GO:0042558	pteridine-containing compound metabolic process
GO:0044237	cellular metabolic process
GO:0046654	tetrahydrofolate biosynthetic process
GO:0046656	folic acid biosynthetic process

	Cellular Component
GO:0005740	mitochondrial envelope

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:6jwr, PDBe:6jwr, PDBj:6jwr
PDBsum	6jwr
PubMed	31883412
UniProt	Q25704

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