Structure of PDB 6jtc Chain B

Receptor sequence
>6jtcB (length=699) Species: 431947 (Porphyromonas gingivalis ATCC 33277) [Search protein sequence]
DEGMWLMQQLGRKYAQMKERGLKMKEYDLYNPNGTSLKDAVVLFDGGCTG
EVVSDRGLVLTNHHCGYDMIQAHSTLEHNYLENGFWAMREADELPNKDIS
VVFIDKIEDVTDYVKKELKAIKDPNSMDYLSPKYLQKLADKKAGKNFSAK
NPGLSVEIKAFYGGNLYLMFTKKTYTDVRLVGAPPSSIGKFGADTDNWIW
PRHTGDFSIFRIYADKNGNPAPYSEDNVPLKPKRFFNISLGGVQENDYAM
IMGFPGTTHRYFTASEVDEWKSIDNDIRIRMRDIRQGVMLREMLADPQIK
IMYSAKYAASQNAYKRAIGANWAIKTRGLRQNKQAMQDRLIAWGAKQGTP
RYEEAVHEIDATVAKRADLRRRYWMIEEGIIRGIEFARSPIPTEDETKAL
QGNDASARKEAIDKIRTRYSKFANKDYSAEVDKKVAVAMLTEYLKEIPYE
NLPLHLRLVKDRFAGDVQAYVDDIFARSVFGSEAQFDAFAAVPSVEKLAE
DPMVLFASSVFDEYRKLYNELRPYDDPILRAQRTYIAGLLEMDGDQDQFP
DANLTLRFTYGQVKGYSPRDNVYYGHQTTLDGVMEKEDPDNWEFVVDPKL
KAVYERKDFGRYADRSGRMPVAFCATTHTTGGNSGSPVMNANGELIGLNF
DRNWEGVGGDIQYLADYQRSIIVDIRYVLLVIDKVGGCQRLLDEMNIVP
3D structure
PDB6jtc Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase.
ChainB
Resolution2.39 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.14.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C8O B N218 W219 T650 T651 G652 N654 S655 N670 F671 D672 R673 N197 W198 T629 T630 G631 N633 S634 N649 F650 D651 R652 MOAD: Ki=8.45uM
Gene Ontology
Molecular Function
GO:0008239 dipeptidyl-peptidase activity
GO:0070009 serine-type aminopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:6jtc, PDBe:6jtc, PDBj:6jtc
PDBsum6jtc
PubMed31537874
UniProtB2RID1|DPP11_PORG3 Asp/Glu-specific dipeptidyl-peptidase (Gene Name=dpp11)

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