Structure of PDB 6jh6 Chain B

Receptor sequence

>6jh6B (length=3454) Species: 9823 (Sus scrofa)

QFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPD
LSICTFVLEQSLSVRALQEMLANTGHRTLLYGHAILLRHSYSGMYLCCLS
TSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILV
SVSSERYLHLSYLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLH
GECLTVPSGEHEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQ
PFRLRHVTTGKYLSLMEDKSLLLMDKEKADVKSTAFTFRSSKDGMGTSEI
KYGDSVCFIQHIGTGLWLTYQSIQRKAIMHHEGHMDDGLNLSRSQHEESR
TARVIRSTVFLFNRFIRGLDALSKKALPIESVSLSLQDLIGYFHPPDEHL
EHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSVAGREAGESW
KSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLH
CVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVR
SNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGKKWYYELMVDHTEP
FVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWS
GCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNI
DGLFFPVVSFSAGIKVRFLLGEFKFLPPPGYAPCYEAVLPKEKLKVEHSR
EYKQERTYTRDLLGPTVSAFTPIPVDTSQIVLPPHLERIREKLAENIHEL
WVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKT
LLALGCHVGISDEHAYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAH
NVWARDRIRQRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLEA
RFRIFRAEKTYAVKAGRWYFEFEAVTAGDMRVGWSRPGCQPDQELGSDER
AFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTMMFTLNGEILL
DDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQ
EGYEPFAVNTNRDITMWLSKRLPQFLQVPSSHEHIEVTRIDVTQKSFGSQ
NSSTDIMFYRLSMPIECTYYYSVRIFPNVWVGWITSDFHQYDTAFDLVTV
TLGDEKGKVHESIKRSNYMVCANNGLEIGCVVGLLTFTANGKDLSTYYQV
EPSTKLFPAVFAQATSPNVFQFEAGLFKSEHKNPVPQCPPRLHVQFLSHV
LWSRMPNQFLKVDVSRISERQGWLVQCLEPLQFMSLHIPEENRSVDILEL
TEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYM
PGLLRAGYYDLLIDIHLSSYATARLMMNNEFIVPMTEETKSITLFPDGLP
GIGLSTSLRPRMQFSSPSFVSINNECYQYSPEFPLDILKAKTIQMLTEAV
QEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPS
GLLQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQR
FRYNEVRDQLLDFHEDLMTHCGIELDSDLTIRGRLLSLVEKVTYLTLQQL
ISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGV
SVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNL
MRALGMHETVMEVMVNVLGFPKMVANCCRFLCYFCRISRQNQKAMFDHLS
YLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYL
AGCGPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPEGLLAAMEE
AIKIGNAIMTFYAALIDLLGRCAEAIRIRSILRSLGDLVGVISIAFQFCP
DHKAAMVLFLDRVYVQDFLLHLLGFLPDLRAAASLTDMALALNRYLCTAV
LPLLLFAGTEHHASLIDSLLHTVKGCSLTKAQRDSIEVCLLSRPSMMQHL
LRRLVFDVPLLNKMPLKLLTNHYERCWKYYCLPGGASEEELHLSRKLFWG
IFDALYEQELFKLALPCLSAVAGALPPNFNPQPVDTSNITIPEKLEYFIN
KYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYR
WPIKESLKTMLAWGWRIERTREGDDAAHGYSPRAIDMSNVTLSRDLHAMA
EMMAENYHNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAKDREKAQD
ILKFLQINGYAVSRGYFLSAASRPLCSGGHASNKEKEMVFCKLGVLVRHR
ISLFGNDATLHILGQTLDARTVMKTGLESVKFLDNAAEDLEKTMENLKQG
QFTTTVALLPMLSSLFEHIGQHQFLEDVQVSCYRILTSLYALGTSVERQR
SALGECLAAFAGAAFLETHLDKHNIYSYNLPRHRAVNLFLQGYEKSWIET
EEHYFEDKLIEDLAKPRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYAD
IMAKSCSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVA
ATLKLGIAILNGGNSTVQQKMLEYLKEKKDVGFFQSLAGLMQSCSVLDLN
AFERQNKAEGKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTT
VNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVF
NTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEL
LKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFF
DMFLKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLL
SCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQT
FLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKE
SKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQIIAYQQKLLNYF
ARNFYNMRMLALFVAFAINFILLFYKVSVHYVLEESSGYMEPTLRILAIL
HTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKG
QWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGVKYQMWK
LGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSS
VTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDM
LTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILL
AIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHT
LQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFR
KQYE

3D structure

• PDB: 6jh6 Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators.
• Chain: B
• Resolution: 4.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	B	R4171 M4885 C4889 T4910 N4915 L4916	R3003 M3375 C3379 T3400 N3405 L3406
BS02	ZN	B	C4889 I4891 C4892 H4914	C3379 I3381 C3382 H3404

Gene Ontology

--> -->

UnboundLocalError

Python 3.6.8: /usr/bin/python3 Tue Nov 26 23:59:26 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '6jh6', asym_id = 'B', title = 'Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='6jh6', asym_id='B', title='Molecular basis for allosteric regulation of the...nodine receptor channel gating by key modulators.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot = '', pdbid = '6jh6', asym_id = 'B'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005216,0005219,0005262,0005509,0006811,0006816,0006874,0016020,0055085,0070588', uniprot='', pdbid='6jh6', asym_id='B')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>