Structure of PDB 6jb3 Chain B

Receptor sequence
>6jb3B (length=671) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
VRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQ
RLCVAFDAQARKGARAIWRALCHAFGRRLILSSTFRILADLLGFAGPLCI
FGIVDHLGKNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTK
IYNKIMHLSTSNTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEHSNERLKQTN
EMLRGMKLLKLYAWESIFCSRVEVTRRKEMTSLRAFAVYTSISIFMNTAI
PIAAVLITFVGHVSFFKESDLSPSVAFASLSLFHILVTPLFLLSSVVRST
VKALVSVQKLSEFLSSPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAI
DYWLAKWTDDQSVYAMVFTLLCSLGIVLCLVTSVTVEWTGLKVAKRLHRS
LLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLC
VSALTVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPL
LSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEV
RMEYIGACVVLIAAATSISNSLAGLVGLGLTYALMVSNYLNWMVRNLADM
EIQLGAVKRIHALLKTEAESY
3D structure
PDB6jb3 The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
ChainB
Resolution3.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BJX B Y377 I381 W430 L434 N437 L592 R1246 E1249 Y133 I137 W180 L184 N187 L342 R596 E599
BS02 AJP B W430 N547 H584 V587 F591 Y1294 W1297 D1304 W180 N297 H334 V337 F341 Y639 W642 D649
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0006813 potassium ion transport
GO:0031669 cellular response to nutrient levels
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0046676 negative regulation of insulin secretion
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0061535 glutamate secretion, neurotransmission
GO:0071805 potassium ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:0098662 inorganic cation transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0032991 protein-containing complex
GO:0098793 presynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6jb3, PDBe:6jb3, PDBj:6jb3
PDBsum6jb3
PubMed31067468
UniProtA0A1U7R319

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