Structure of PDB 6irw Chain B

Receptor sequence
>6irwB (length=491) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQGSHVYWDLDIQTNAVIKHRGPSEVLPPHPEVELLRSQLILKLRQ
HYRELCQQREGIEPPRESFNRWMLERKVVDKGSDPLLPSNCEPVVSPSMF
REIMNDIPIRLSFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVE
DTFSWLRKDHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHI
SLEYVKRIREKHLAILKENNISEEVEAPEVEPRLVYCYPVRLAVSAPPMP
SVEMHMENNVVCIRYKGEMVKVSRNYFSKLWLLYRYSCIDDSAFERFLPR
VWCLLRRYQMMFQGSLPVHVFEALHRLFGVSFECFASPLNCYFRQYCSAF
PDTDGYFGSRGPCLDFAPLSGSFEANPPFCEELMDAMVSHFERLLESSPE
PLSFIVFIPEWREPPTPALTRMEQSRFKRHQLILPAFEHEYRSGSQHICK
KEEMHYKAVHNTAVLFLQNDPGFAKWAPTPERLQELSAAYR
3D structure
PDB6irw Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II-associated methyltransferase.
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.62: mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH B L238 S492 L493 E510 F512 A513 N517 C524 S525 A526 C540 E551 N553 P555 L74 S315 L316 E333 F335 A336 N340 C347 S348 A349 C363 E374 N376 P378
Gene Ontology
Molecular Function
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
GO:0099122 RNA polymerase II C-terminal domain binding

View graph for
Molecular Function
External links
PDB RCSB:6irw, PDBe:6irw, PDBj:6irw
PDBsum6irw
PubMed30467178
UniProtQ9H4Z3|CAPAM_HUMAN mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (Gene Name=PCIF1)

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