Structure of PDB 6iq5 Chain B

Receptor sequence
>6iq5B (length=437) Species: 9606 (Homo sapiens) [Search protein sequence]
QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR
PSFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLE
GHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHD
DPEFRELLVDVMPWPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPG
AAPRDMMDAFILSAEKKAAARLDLENVPATITDIFGASQDTLSTALQWLL
LLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSS
FVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPA
RFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDF
RANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLD
3D structure
PDB6iq5 Design and synthesis of selective CYP1B1 inhibitor via dearomatization of alpha-naphthoflavone.
ChainB
Resolution3.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
4.2.1.152: hydroperoxy icosatetraenoate dehydratase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM B R117 A133 R145 I327 A330 S331 T334 F394 T398 H401 I462 F463 S464 R468 C470 I471 G472 S476 R50 A66 R78 I234 A237 S238 T241 F301 T305 H308 I369 F370 S371 R375 C377 I378 G379 S383
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:6iq5, PDBe:6iq5, PDBj:6iq5
PDBsum6iq5
PubMed30553624
UniProtQ16678|CP1B1_HUMAN Cytochrome P450 1B1 (Gene Name=CYP1B1)

[Back to BioLiP]