Structure of PDB 6ilh Chain B

Receptor sequence
>6ilhB (length=504) Species: 9606 (Homo sapiens) [Search protein sequence]
DPNQYYKIRSQAIHQLKVNGEDPYPHKFHVDISLTDFIQKYSHLQPGDHL
TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIH
INNKLRRGDIIGVQGNPGKTKKGELSIIPYEITLLSPCLHMLPHLHFGLK
DKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMM
NIIPGGAVAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQ
FRNEGIDLTHNPEFTTCEFYMAYADYHDHMEITEKMVSGMVKHITGSYKV
TYHPDGPEGQAYDVDFTPPFRRINMVEELEKALGMKLPETNLFETEETRK
ILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSP
LAKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAA
GDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP
AMKP
3D structure
PDB6ilh Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
ChainB
Resolution2.501 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.-
6.1.1.6: lysine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KAA B E301 R323 H331 N332 F335 E339 Y341 E494 N497 Y499 E501 G546 G548 G550 R553 E230 R252 H260 N261 F264 E268 Y270 E423 N426 Y428 E430 G475 G477 G479 R482
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ilh, PDBe:6ilh, PDBj:6ilh
PDBsum6ilh
PubMed30733335
UniProtQ15046|SYK_HUMAN Lysine--tRNA ligase (Gene Name=KARS1)

[Back to BioLiP]