Structure of PDB 6iih Chain B

Receptor sequence
>6iihB (length=437) Species: 9606,10665 [Search protein sequence]
MNIFEMLRIDERLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAI
GRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALI
NMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSIWYNQTPNRAKRVI
TTFRTGTWDAYHMLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQMEKK
LTKKDIEDTLSGIQTAGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSG
FHVAFKMLDTDGNEMIEKREFFKNTTLQMRFFGKRGQRKLHYKEFRRFME
NLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTENKDIYWKNVREKL
SAGESISLDEFKSFCHFTTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVA
TGQELSNNILDTVFKIFDLDGDECLSHEEFLGVLKNR
3D structure
PDB6iih The crystal structure of MICU2 provides insight into Ca2+binding and MICU1-MICU2 heterodimer formation.
ChainB
Resolution1.958 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D264 D266 N268 M270 E275 D259 D261 N263 M265 E270
BS02 CA B D454 D456 D458 C460 E465 D418 D420 D422 C424 E429
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0006851 mitochondrial calcium ion transmembrane transport
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6iih, PDBe:6iih, PDBj:6iih
PDBsum6iih
PubMed31397067
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E);
Q8IYU8|MICU2_HUMAN Calcium uptake protein 2, mitochondrial (Gene Name=MICU2)

[Back to BioLiP]