Structure of PDB 6ieg Chain B

Receptor sequence
>6iegB (length=911) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLMPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDA
FQREAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIK
ALSNQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEV
MREVAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQF
AEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDN
FNTAMQVLRDSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDF
NTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLP
ILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRW
ISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNS
AFHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQ
YNKIVIPNEESVVIYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVK
VKNEGDDFGWGVVVNFSKKSDPLYVVEVLLRCSKESLKNSAAKPAKPDEK
GEMQVVPVLVHLLSAISSVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDG
IPLLDPIDDMGIQDQGLKKVIQKVEAFEHRMYSHPLHNDPNLETVYTLCE
KKAQIAIDIKSAKRELKTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRV
ACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTE
QLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATG
ATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEG
ITKIKRDIVFA
3D structure
PDB6ieg NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
ChainB
Resolution3.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B F138 D141 T163 A165 G166 K167 T168 F46 D49 T71 A73 G74 K75 T76
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0000460 maturation of 5.8S rRNA
GO:0006364 rRNA processing
GO:0006397 mRNA processing
GO:0006401 RNA catabolic process
GO:0006974 DNA damage response
GO:0008380 RNA splicing
GO:0016076 snRNA catabolic process
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0031499 TRAMP complex
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ieg, PDBe:6ieg, PDBj:6ieg
PDBsum6ieg
PubMed30842217
UniProtP42285|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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