Structure of PDB 6ic5 Chain B

Receptor sequence
>6ic5B (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
HLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQ
TPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDS
PCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDD
FLHYKKGIYHHT
3D structure
PDB6ic5 Structure-based design and in vivo anti-arthritic activity evaluation of a potent dipeptidyl cyclopropyl nitrile inhibitor of cathepsin C.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q228 C234
Catalytic site (residue number reindexed from 1) Q23 C29
Enzyme Commision number 3.4.14.1: dipeptidyl-peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HB5 B G232 C234 E275 G276 G277 F278 A349 G27 C29 E70 G71 G72 F73 A144 PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:6ic5, PDBe:6ic5, PDBj:6ic5
PDBsum6ic5
PubMed30978322
UniProtP53634|CATC_HUMAN Dipeptidyl peptidase 1 (Gene Name=CTSC)

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