Structure of PDB 6i8l Chain B

Receptor sequence
>6i8lB (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
NIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLE
LNKDERVSALEVLPDRVATLADTMIGKAVEHMFETEDGSKDEWRGMVLAR
APVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSSLVGKQVEYAKS
KRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTSAENLYFQ
3D structure
PDB6i8l A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
ChainB
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H7Q B D95 H139 F141 W151 Y170 Y179 D184 D44 H81 F83 W93 Y112 Y121 D126 PDBbind-CN: -logKd/Ki=6.41,IC50=0.39uM
BindingDB: IC50=390nM
Gene Ontology
Biological Process
GO:0007276 gamete generation

View graph for
Biological Process
External links
PDB RCSB:6i8l, PDBe:6i8l, PDBj:6i8l
PDBsum6i8l
PubMed31550156
UniProtQ9Y657|SPIN1_HUMAN Spindlin-1 (Gene Name=SPIN1)

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