Structure of PDB 6i8b Chain B

Receptor sequence
>6i8bB (length=194) Species: 9606 (Homo sapiens) [Search protein sequence]
RRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYG
LELNKDERVSALEVLPDRVATHLADTMIGKAVEHMFETDGSKDEWRGMVL
ARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSLVGKQVEYAG
SKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTSAENLYFQ
3D structure
PDB6i8b A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
ChainB
Resolution1.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H7T B W62 W72 Y91 F94 Y98 H139 F141 W151 Y170 Y179 D184 W13 W23 Y42 F45 Y49 H84 F86 W95 Y114 Y123 D128 PDBbind-CN: -logKd/Ki=8.00,Kd=9.9nM
BindingDB: Kd=111nM,EC50=270nM,IC50=33nM
BS02 H7T B R51 A119 R2 A70 PDBbind-CN: -logKd/Ki=8.00,Kd=9.9nM
BindingDB: Kd=111nM,EC50=270nM,IC50=33nM
Gene Ontology
Biological Process
GO:0007276 gamete generation

View graph for
Biological Process
External links
PDB RCSB:6i8b, PDBe:6i8b, PDBj:6i8b
PDBsum6i8b
PubMed31550156
UniProtQ9Y657|SPIN1_HUMAN Spindlin-1 (Gene Name=SPIN1)

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