Structure of PDB 6i6t Chain B

Receptor sequence
>6i6tB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
GGLGRAVCLLTGASRGFGRTLAPLLASLLSPGSVLVLSARNDEALRQLEA
ELGAERSGLRVVRVPADLGAEAGLQQLLGALRELPRPKGLQRLLLINNAG
SLGDVSKGFVDLSDSTQVNNYWALNLTSMLCLTSSVLKAFPDSPGLNRTV
VNISSLCALQPFKGWALYCAGKAARDMLFQVLALEEPNVRVLNYAPGPLD
TDMQQLARETSVDPDMRKGLQELKAKGKLVDCKVSAQKLLSLLEKDEFKS
GAHVDFYDK
3D structure
PDB6i6t Fragment-Based Discovery of Novel Potent Sepiapterin Reductase Inhibitors.
ChainB
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.153: sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP B G14 S16 R17 G18 R42 N43 D69 L70 N100 L126 I155 Y170 K174 P198 L201 T203 M205 G12 S14 R15 G16 R40 N41 D67 L68 N98 L124 I153 Y168 K172 P196 L199 T201 M203
BS02 H5B B S157 L158 W167 L222 L225 S155 L156 W165 L220 L223
BS03 H5B B V9 L83 R84 L86 R88 F142 V7 L81 R82 L84 R86 F140
Gene Ontology
Molecular Function
GO:0004033 aldo-keto reductase (NADPH) activity
GO:0004757 sepiapterin reductase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006809 nitric oxide biosynthetic process
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:6i6t, PDBe:6i6t, PDBj:6i6t
PDBsum6i6t
PubMed31244106
UniProtP35270|SPRE_HUMAN Sepiapterin reductase (Gene Name=SPR)

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