Structure of PDB 6i5f Chain B

Receptor sequence
>6i5fB (length=777) Species: 562 (Escherichia coli) [Search protein sequence]
NFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISL
TKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEGPVERKVVRIV
TPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRE
TMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLN
LQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQ
DSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMP
VRDTRVLLERQQTIGALQDFTAGLQPVLRQVGDLERILARLALRTARPRD
LARMRHAFQQLPELRAQLETVDSAPVQALREKMGEFAELRDLLERAIIDT
PPVLVRDGGVIASGYNEELDEWRALADGATDYLERLEVRERERTGLDTLK
VGFNAVHGYYIQISRGQSHLAPINYMRRQTLKNAERYIIPELKEYEDKVL
TSKGKALALEKQLYEELFDLLLPHLEALQQSASALAELDVLVNLAERAYT
LNYTCPTFIDKPGIRITEGRHPVVEQVLNEPFIANPLNLSPQRRMLIITG
PNMGGKSTYMRQTALIALMAYIGSYVPAQKVEIGPIDRIFTRVGRSTFMV
EMTETANILHNATEYSLVLMDEIGRGTSTYDGLSLAWACAENLANKIKAL
TLFATHYFELTQLPEKMEGVANVHLDALEHGDTIAFMHSVQDGAASKSYG
LAVAALAGVPKEVIKRARQKLRELESI
3D structure
PDB6i5f Sharp kinking of a coiled-coil in MutS allows DNA binding and release.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B F596 I597 N616 M617 G619 K620 S621 T622 H760 F582 I583 N602 M603 G605 K606 S607 T608 H738
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
GO:0016887 ATP hydrolysis activity
GO:0030983 mismatched DNA binding
GO:0032136 adenine/cytosine mispair binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0000018 regulation of DNA recombination
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0006974 DNA damage response
Cellular Component
GO:0005829 cytosol
GO:0032300 mismatch repair complex
GO:1990710 MutS complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6i5f, PDBe:6i5f, PDBj:6i5f
PDBsum6i5f
PubMed31372631
UniProtP23909|MUTS_ECOLI DNA mismatch repair protein MutS (Gene Name=mutS)

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