Structure of PDB 6i3p Chain B

Receptor sequence

>6i3pB (length=623) Species: 759272 (Thermochaetoides thermophila DSM 1495)

SIKEQRESLPVFQFRDQIIQAVKDNQILIVVGETGSGKTTQVTQYLAEAG
FTKYGMIGCTQPRRVAAVSVAKRVAEEVGCQLGQEVGYTIRFEDVTSPAT
KIKYMTDGMLQREILMDPDLKRYSVIMLDEAHERTIATDVLFALLKKTVK
RRPDLKVIVTSATLDAEKFSEYFNSCPIFTIPGRTFPVEILYSREPEPDY
LEAALTTVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKALGPSVPE
LIILPIYSALPSEMQSRIFEPAGSRKVVIATNIAETSITIDYIYYVVDPG
FVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTEAAY
QSEMLPTTIPDIQRQNLANTILLLKAMGINDLLRFDFMDPPPVNTMLTAL
EELYALGALDDEGLLTRLGRKMADFPMEPSLSKVLIASVDKGCSDEMVTI
VSMLNLQQIFYRPKDKQQQADQKKAKFHDPTGDHLTLLNVYNAWKNSGYS
NAWCFENYIQARAMRRARDVRQQIVKIMERHRHPIISCGRDTDKIRQALC
AGFFRNTARKDPGYKTLTEGTPVYLHPSSALFGKQAEWVLYHELVLTTKE
YMHFTTAIEPKWLVEAAPTFFKL

3D structure

• PDB: 6i3p Structural basis for RNA translocation by DEAH-box ATPases.
• Chain: B
• Resolution: 2.75 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	R611 R612 R639 T654 M657 R660 G774 Q775 E776 S806 T831 N832 S837 K853 L866 P976 R1012 Q1073 H1128 P1129 F1134 T1149 K1151 Y1153 H1155	R63 R64 R91 T106 M109 R112 G226 Q227 E228 S258 T281 N282 S287 K303 L316 P426 R462 Q523 H576 P577 F582 T597 K599 Y601 H603

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6i3p, PDBe:6i3p, PDBj:6i3p
• PDBsum: 6i3p
• PubMed: 30828714
• UniProt: G0S700