Structure of PDB 6i2y Chain B

Receptor sequence
>6i2yB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
EHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETEEEL
EDYIVEIEILATCDHPYIVKLLGAYYHDGLWIMIEFCPGGAVDAIMLELD
RGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADF
GVSAKNIGTPYWMAPEVVMCETPYDYKADIWSLGITLIEMAQIEPPHHEL
NPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLAIALDKNPETRPSAAQLLE
HPFVSSITSNKALRELVAEAKAEVMEE
3D structure
PDB6i2y Human STK10 bound to GW683134
ChainB
Resolution2.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D157 K159 G161 N162 D175 T195
Catalytic site (residue number reindexed from 1) D131 K133 G135 N136 D149 T159
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 88Z B L42 A63 L85 I110 C113 G116 L164 A174 D175 F176 L19 A40 L60 I84 C87 G90 L138 A148 D149 F150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6i2y, PDBe:6i2y, PDBj:6i2y
PDBsum6i2y
PubMed
UniProtO94804|STK10_HUMAN Serine/threonine-protein kinase 10 (Gene Name=STK10)

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