Structure of PDB 6i2p Chain B

Receptor sequence
>6i2pB (length=266) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TTPSHLSDRYELGEILGFGGMSEVHLARDLREHRDVAVKVLRADLARDPS
FYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLR
DIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNA
VKVMDFGIANSVTQTAATAQYLSPEQARGDSVDARSDVYSLGCVLYEVLT
GEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPEN
RYQTAAEMRADLVRVH
3D structure
PDB6i2p Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
ChainB
Resolution2.37 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D138 K140 N143 D156 T179
Catalytic site (residue number reindexed from 1) D137 K139 N142 D155 T168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP B G18 F19 G20 G21 V25 A38 K40 M92 V95 M145 G17 F18 G19 G20 V24 A37 K39 M91 V94 M144
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:6i2p, PDBe:6i2p, PDBj:6i2p
PDBsum6i2p
PubMed31064884
UniProtP9WI81|PKNB_MYCTU Serine/threonine-protein kinase PknB (Gene Name=pknB)

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