Structure of PDB 6i0o Chain B

Receptor sequence
>6i0oB (length=431) Species: 9606 (Homo sapiens) [Search protein sequence]
SYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKY
EQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISS
RDIDFLKEHDCFLEEIMTKREDLVVAPAGITLKEANEILQRSKKGKLPIV
NEDDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDL
LAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKN
LIDAGVDALRVGMGEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNV
GHIAKALALGASTVMMGSLLAATTEAPGEYFFDKGSIHKFVPYLIAGIQH
SCQDIGAKSLTQVRAMMYSGELKFEKRTSSA
3D structure
PDB6i0o A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity.
ChainB
Resolution2.623 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B I157 S159 S160 R161 D162 L185 V186 K206 G207 I147 S149 S150 R151 D152 L173 V174 K194 G195
BS02 GTP B Q112 F139 C140 G141 S160 K208 T225 D226 K229 Q102 F129 C130 G131 S150 K196 T213 D214 K217
BS03 GTP B E111 N198 L227 N230 P234 K238 K242 E101 N186 L215 N218 P222 K226 K230
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
GO:0007623 circadian rhythm
GO:0046651 lymphocyte proliferation
GO:0071353 cellular response to interleukin-4
GO:0097294 'de novo' XMP biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6i0o, PDBe:6i0o, PDBj:6i0o
PDBsum6i0o
PubMed30664871
UniProtP12268|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (Gene Name=IMPDH2)

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