Structure of PDB 6i0m Chain B

Receptor sequence
>6i0mB (length=444) Species: 9606 (Homo sapiens) [Search protein sequence]
SYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKY
EQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDGRMGSRLVIISSRD
IDFLEHDCFLEIMTKRLVVAPAGITLKEANEILQRSKKGKLPIVNEDELV
AIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLAQAGVD
VVVLDSSQGNSIFQINMIKYIKDKYPNLQVIGGNVVTAAQAKNLIDAGVD
ALRVGMGSGSITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVG
HIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRQDKGSIHKFVPYLI
AGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGKRLF
3D structure
PDB6i0m A Nucleotide-Dependent Conformational Switch Controls the Polymerization of Human IMP Dehydrogenases to Modulate their Catalytic Activity.
ChainB
Resolution2.567 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5GP B S68 R322 G328 T333 D364 G387 S388 S58 R303 G309 T312 D343 G366 S367
BS02 GDP B S159 R161 D162 K206 G207 S147 R149 D150 K188 G189
BS03 GDP B P118 F139 C140 G141 K208 T225 D226 K229 P108 F129 C130 G131 K190 T206 D207 K210
BS04 GDP B E111 Q112 N198 N230 K242 E101 Q102 N180 N211 K223
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
GO:0007623 circadian rhythm
GO:0046651 lymphocyte proliferation
GO:0071353 cellular response to interleukin-4
GO:0097294 'de novo' XMP biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6i0m, PDBe:6i0m, PDBj:6i0m
PDBsum6i0m
PubMed30664871
UniProtP12268|IMDH2_HUMAN Inosine-5'-monophosphate dehydrogenase 2 (Gene Name=IMPDH2)

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