Structure of PDB 6hys Chain B

Receptor sequence
>6hysB (length=633) Species: 9606 (Homo sapiens) [Search protein sequence]
QMSILEQRESLPIYKLKEQLVQAVHDNQILIVIGETGSGKTTQITQYLAE
AGYTSRGKIGCTQPRRVAAMSVAKRVSEEFGCCLGQEVGYTIRFEDCTSP
ETVIKYMTDGMLLRECLIDPDLTQYAIIMLDEAHERTIHTDVLFGLLKKT
VQKRQDMKLIVTSATLDAVKFSQYFYEAPIFTIPGRTYPVEILYTKEPET
DYLDASLITVMQIHLTEPPGDILVFLTGQEEIDTACEILYERMKSLGPDV
PELIILPVYSALPSEMQTRIFDPAPPGSRKVVIATNIAETSLTIDGIYYV
VDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYT
ERAYRDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETL
ITAMEQLYTLGALDDEGLLTRLGRRMAEFPLEPMLCKMLIMSVHLGCSEE
MLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQTEGDHLTLLAVYNSWKN
NKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKSTVRVQ
KAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHEL
VLTTKEYMREVTTIDPRWLVEFAPAFFKVSDPT
3D structure
PDB6hys Structural and functional characterisation of human RNA helicase DHX8 provides insights into the mechanism of RNA-stimulated ADP release.
ChainB
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B T590 G591 S592 G593 K594 T595 T596 S625 R629 F825 T847 D849 T36 G37 S38 G39 K40 T41 T42 S71 R75 F271 T293 D295
BS02 MG B T595 E686 T41 E132
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hys, PDBe:6hys, PDBj:6hys
PDBsum6hys
PubMed31409651
UniProtQ14562|DHX8_HUMAN ATP-dependent RNA helicase DHX8 (Gene Name=DHX8)

[Back to BioLiP]