Structure of PDB 6hs4 Chain B

Receptor sequence

>6hs4B (length=130) Species: 128952 (Ebola virus - Mayinga, Zaire, 1976) [Search protein sequence]

EAIVNAQPKCNPNLHYWTTQDEGAAIGLAWIPYFGPAAEGIYIEGLMHNQ
DGLICGLRQLANETTQALQLFLRATTELRTFSILNRKAIDFLLQRWGGTC
HILGPDCCIEPADWTKNITDKIDQIIHDFV

3D structure

PDB

6hs4 Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.

Chain

Resolution

2.05 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GON	B	M548 L554	M47 L53	PDBbind-CN: -logKd/Ki=5.51,IC50=3.1uM
BS02	GON	B	L515 Y517 T519 D522 M548	L14 Y16 T18 D21 M47	PDBbind-CN: -logKd/Ki=5.51,IC50=3.1uM

External links

PDB	RCSB:6hs4, PDBe:6hs4, PDBj:6hs4
PDBsum	6hs4
PubMed	30785281
UniProt	Q05320\|VGP_EBOZM Envelope glycoprotein (Gene Name=GP)