Structure of PDB 6hmx Chain B

Receptor sequence
>6hmxB (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLRKDVL
REAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYP
DVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIAD
FGLSKWRMGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQP
FEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPD
ERPSFLKCLIELEPVLRTFEEITFLEAVIQLK
3D structure
PDB6hmx Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ChainB
Resolution2.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 Q150 N151 D164
Catalytic site (residue number reindexed from 1) D132 Q136 N137 D150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GEZ B L24 S25 A45 K47 T95 M98 G101 E105 L153 L20 S21 A41 K43 T81 M84 G87 E91 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6hmx, PDBe:6hmx, PDBj:6hmx
PDBsum6hmx
PubMed30344914
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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