Structure of PDB 6hmp Chain B

Receptor sequence
>6hmpB (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVHPQLHIES
KIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLK
TVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLA
KKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVL
MYFNLGSLPWQRISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPD
YSYLRQLFRNLFHRQGFSYDYVFDWNML
3D structure
PDB6hmp 2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.
ChainB
Resolution2.039 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
2.7.11.26: [tau protein] kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GEW B R13 S17 G18 I23 A36 K38 M80 M82 L85 G86 P87 K130 D132 L135 I148 R13 S17 G18 I23 A36 K38 M77 M79 L82 G83 P84 K127 D129 L132 I145 MOAD: ic50=218nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6hmp, PDBe:6hmp, PDBj:6hmp
PDBsum6hmp
PubMed30924488
UniProtP48730|KC1D_HUMAN Casein kinase I isoform delta (Gene Name=CSNK1D)

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