Structure of PDB 6hkx Chain B

Receptor sequence
>6hkxB (length=323) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAHSIVECDPVRKEVSVRTGGSSRKTYTFDMVFGAST
KQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYT
WEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSS
DVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAAT
LMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQS
LLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASL
NLEETLSTLEYAHRAKNILNKPE
3D structure
PDB6hkx Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B R24 R26 P27 T107 G108 T109 G110 K111 T112 F113 E118 R8 R10 P11 T81 G82 T83 G84 K85 T86 F87 E92
BS02 GCE B E116 G117 W127 A133 Y211 L214 E215 G217 A218 R221 F239 E90 G91 W101 A107 Y185 L188 E189 G191 A192 R195 F213 PDBbind-CN: -logKd/Ki=9.34,Kd=456.3pM
BindingDB: IC50=6.0nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:6hkx, PDBe:6hkx, PDBj:6hkx
PDBsum6hkx
PubMed31488701
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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