Structure of PDB 6hh5 Chain B

Receptor sequence
>6hh5B (length=328) Species: 7897 (Latimeria chalumnae) [Search protein sequence]
MVSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKAGT
LFYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGVVQ
VFKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDVIK
FARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEMERI
EGKLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYSFLH
CMESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMDQVT
PSWKRSCEAIVETEESAVKLYELYCKQL
3D structure
PDB6hh5 (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B T62 D63 D64 D305 T54 D55 D56 D280
BS02 A3R B D63 G101 G103 G105 V106 F129 S134 Y135 G136 N137 G138 H168 I260 D55 G93 G95 G97 V98 F121 S126 Y127 G128 N129 G130 H160 I235
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0060546 negative regulation of necroptotic process
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Cellular Component
External links
PDB RCSB:6hh5, PDBe:6hh5, PDBj:6hh5
PDBsum6hh5
PubMed30472116
UniProtH3BCW1|ADPRS_LATCH ADP-ribosylhydrolase ARH3 (Gene Name=adprs)

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