Structure of PDB 6hh4 Chain B

Receptor sequence

>6hh4B (length=329) Species: 7897 (Latimeria chalumnae)

MVSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKAGT
LFYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGVVQ
VFKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDVIK
FARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEMERI
EGGKLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYSFL
HCMESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMDQV
TPSWKRSCEAIVETEESAVKLYELYCKQL

3D structure

• PDB: 6hh4 (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.
• Chain: B
• Resolution: 1.66 Å

Enzymatic activity

• Enzyme Commision number: 3.2.1.143: poly(ADP-ribose) glycohydrolase.
  3.2.2.-
  3.5.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	B	T62 D63 D64 D305	T54 D55 D56 D281
BS02	MG	B	E33 D303 D305 T306	E25 D279 D281 T282
BS03	F2R	B	E33 D63 D64 G101 Y102 G103 G105 V106 F129 S134 Y135 G136 N137 G138 H168 I260 D303 D305 T306	E25 D55 D56 G93 Y94 G95 G97 V98 F121 S126 Y127 G128 N129 G130 H160 I236 D279 D281 T282

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004649 poly(ADP-ribose) glycohydrolase activity
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006281 DNA repair
• GO:0060546 negative regulation of necroptotic process
• GO:0140290 peptidyl-serine ADP-deribosylation

Cellular Component

• GO:0005634 nucleus
• GO:0005694 chromosome
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005759 mitochondrial matrix

External links

• PDB: RCSB:6hh4, PDBe:6hh4, PDBj:6hh4
• PDBsum: 6hh4
• PubMed: 30472116
• UniProt: H3BCW1|ADPRS_LATCH ADP-ribosylhydrolase ARH3 (Gene Name=adprs)