Structure of PDB 6hgb Chain B

Receptor sequence
>6hgbB (length=389) Species: 383550 (Influenza A virus (A/duck/England/1/1956(H11N6))) [Search protein sequence]
RTFLNLTKPLCEVNSWHILSKDNAIRIGEDAHILVTREPYLSCDPQGCRM
FALSQGTTLRGRHANGTIHDRSPFRALISWEMGQAPSPYNTRVECIGWSS
TSCHDGMSRMSICMSGPNNNASAVVWYGGRPITEIPSWAGNILRTQESEC
VCHKGVCPVVMTDGPANNRAATKIIYFKEGKIQKIEELAGNAQHIEECSC
YGAGGVIKCICRDNWKGANRPVITIDPEMMTHTSKYLCSKVLTDTSRPND
PTNGNCDAPITGGSPDPGVKGFAFLDGENSWLGRTISKDSRSGYEMLKVP
NAETDIQSGPISNQVIVNNQNWSGYSGAFIDYWANKECFNPCFYVELIRG
RPKESSVLWTSNSIVALCGSKKRLGSWSWHDGAEIIYFE
3D structure
PDB6hgb High Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation)
ChainB
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D151 E278 R293 R372 Y406
Catalytic site (residue number reindexed from 1) D70 E197 R212 R291 Y325
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA B S393 N394 S312 N313
BS02 MAN B P391 N394 P310 N313
BS03 MAN B E376 N394 E295 N313
BS04 MAN B D331 R365 D250 R284
BS05 CA B D294 G298 D325 P348 D213 G217 D244 P267
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6hgb, PDBe:6hgb, PDBj:6hgb
PDBsum6hgb
PubMed
UniProtQ6XV27|NRAM_I56A2 Neuraminidase (Gene Name=NA)

[Back to BioLiP]