Structure of PDB 6hdu Chain B

Receptor sequence
>6hduB (length=170) Species: 9606 (Homo sapiens) [Search protein sequence]
HMQAPHKEHLYKLLVIGDLGVGKTSIIKRYVHQNFSSHYRATIGVDFALK
VLHWDPETVVRLQLWDIAGLERFGNMTRVYYREAMGAFIVFDVTRPATFE
AVAKWKNDLDSKLSLPNGKPVSVVLLANKCDQMDQFCKEHGFVGWFETSA
KENINIDEASRCLVKHILAN
3D structure
PDB6hdu LRRK2 binds to the Rab32 subfamily in a GTP-dependent mannerviaits armadillo domain.
ChainB
Resolution1.793 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B L18 G19 G21 K22 T23 S24 F34 S36 Y38 A40 T41 G68 K128 D130 S159 K161 L19 G20 G22 K23 T24 S25 F35 S37 Y39 A41 T42 G69 K129 D131 S149 K151 MOAD: Kd=1.2uM
BS02 MG B T23 T41 T24 T42
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0031982 vesicle

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Cellular Component
External links
PDB RCSB:6hdu, PDBe:6hdu, PDBj:6hdu
PDBsum6hdu
PubMed31552791
UniProtP57729|RAB38_HUMAN Ras-related protein Rab-38 (Gene Name=RAB38)

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